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Octreotide Acetate

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产品编号 T4119Cas号 79517-01-4
别名 醋酸奥曲肽, SMS 201-995 (acetate), SMS 201995, Sandostatin, Longastatin

Octreotide Acetate (Sandostatin) 是一种长期有效的合成生长抑素八肽类似物,可抑制生长激素的分泌。

Octreotide Acetate

Octreotide Acetate

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纯度: 99.87%
产品编号 T4119 别名 醋酸奥曲肽, SMS 201-995 (acetate), SMS 201995, Sandostatin, LongastatinCas号 79517-01-4

Octreotide Acetate (Sandostatin) 是一种长期有效的合成生长抑素八肽类似物,可抑制生长激素的分泌。

规格价格库存数量
5 mg¥ 242现货
10 mg¥ 413现货
25 mg¥ 618现货
50 mg¥ 897现货
100 mg¥ 1,370现货
200 mg¥ 1,980期货
1 mL x 10 mM (in DMSO)¥ 490现货
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TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性
产品描述
Octreotide Acetate (Sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.
体内活性
Octreotide处理组与盐水组相比,肿瘤体积显著减少。Octreotide-PPSG(1.4 mg/kg,i.p.)的抗肿瘤效果超过Octreotide-soln(100 μg/kg,i.p.)。Octreotide处理在原发性HCC携带大鼠中显著抑制SSTR2和SSTR5的表达水平,与盐水组相比。Octreotide-PPSG对SSTR2和SSTR5的表达抑制作用大于Octreotide-soln处理组。 Octreotide Acetate 盐试验剂量在2小时内将血清胃泌素水平显著降低至基线的约三分之一,效果持续约6小时。第21天,开始使用持续释放配方的 Octreotide Acetate 盐(5 mg肌内注射,每4周一次)。
动物实验
Octreotide (acetate) is formulated in saline.MiceThirty mice with HCC xenografts are randomLy divided into three groups: (A) Octreotide-soln group, (B) Octreotide-PPSG group, and (C) control group. Octreotide-soln group receives i.p. injection of 100 μg/kg octreotide-soln once a day and totally for consecutive 14 days. Octreotide-PPSG group receives a single subcutaneous injection of 1.4 mg/kg Octreotide-PPSG, and the injection volume is about 0.2 mL. Control group receives i.p. injection of saline once a day for consecutive 14 days. Treatment starts on the next day after injection of H22 hepatoma cell suspension and maintains for 14 days. Tumor growth is monitored by periodic caliper measurements on day 7 and day 14 post seeding. Tumor volumes (V) are calculated based on the length and width of tumor by Eq. RatTwelve male SD rats are divided into two groups, and housed in standard cages at 25°C, with free access to food and water for a week prior to the experiment. Rats are subcutaneously injected with Octreotidereotide solution (Octreotide-soln) or Octreotide-PPSG at an equivalent single dose of 20 mg/kg. The dose is determined based on the clinical dose of Octreotide-soln in human. Rats are fasted for 12 h before dosing and food is returned approximately 2 h post dosing. Blood samples are collected at predetermined time points using heparinized Eppendorf tubes. Immediately after collection, the blood samples are placed on ice until centrifuged at 3000 g for 10 min within 1 h. The plasma is collected and stored at ?20°C until analysis.
别名醋酸奥曲肽, SMS 201-995 (acetate), SMS 201995, Sandostatin, Longastatin
化学信息
分子量1079.3
分子式C51H70N10O12S2
CAS No.79517-01-4
SmilesCC(O)=O.C[C@@H](O)[C@@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1
密度1.395 g/cm3
储存&溶解度
存储keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 29 mg/mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

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